Moringa Oleifera's Protective Effect Against DNA Damage from Hydroxychloroquine

Background :- the objective of this research was to investigate if powdered Moringa oleifera leaves could offer protection to genetic material from hydroxychloroquine-induced damage, male albino rats were utilized. They were given dry Moringa leaf powder with lunch for three weeks. Additionally, they were administered hydroxychloroquine treatment at various doses every day for five days. Results:- The the data indicate the presence of malondialdehyde (MDA) in serum. Liver DNA damage was examined using the Comet test and (SCGE) techniques in addition to assessing the superoxide dismutase (SOD) enzyme. MDA increased while SOD dropped otherwise. Subsequent to the administration of with powdered Moringa oleifera leaf, the activity of antioxidant factors was raised and the MDA level and were decreased. it can be inferred from these findings that, hydroxychloroquine is genotoxic at the dosages utilized, and the liver is a major target organ. In addition to exhibiting a protective role against HCQ-induced DNA damage, M. oleifera demonstrated slight genetic alterations. - Level of lipid peroxide (MDA): The HCQ groups exhibited a substantial increase in lipid peroxide (Malone di-aldehyde) activity when compared to the normal group. - Antioxidants (SOD): It was discovered that the HCQ groups had markedly reduced superoxide oxidase (SOD) activity than the control group. Enzyme activity, however, was notably elevated in the M. oleifera-treated groups (P = 0.001).