Study of (IL17A) Genetic Variant (rs 2275913 ) and its Association with Reduced Risk of Multiple Sclerosis Disease in Egyptian Patients

Background: Multiple sclerosis (MS) is an autoimmune disease that often affects young and middle-aged adults. Genetic single nucleotide polymorphisms (SNPs) as genetic biomarkers are connected to MS. Aim of the work: The aim of this work was to study the role of IL17A genetic variant (rs2275913 ) and its association with reduced risk of MS disease in Egyptian patients . Patients & Methods: This cross-sectional study included 50 participants; 30 MS patients recruited from MS Unit of Department of Neuropsychiatry and outpatient clinic of Benha University Hospitals and 20 apparently healthy control candidates. In the present study the relation of rs2275913 A/G polymorphism in IL17A gene variations with the risk of MS has been investigated. DNAs were extracted from blood samples and genotyping was performed for rs2275913 with XagΙ by PCR-RFLP method. Then the association of frequency of alleles and genotypes with the risk of disease was analyzed. Results: revealed that the IL17A (rs2275913) gene polymorphism has significant genotype differences between MS patients and controls, notably for the AA genotype (p = 0.027), which appears to be related with a decreased risk of MS (OR = 0.29). The A allele is also considerably less prevalent in MS patients.Conclusion: The IL17A (rs2275913) gene polymorphism has been linked to MS. The IL17A GG genotype is associated with higher disability levels while the AA genotype may offer some protection against severe disability.