September 29, 2025Jurnal Ilmiah MedicamentoOpen Access

Antibiotic Consumption and Its Influence on Escherichia coli and Klebsiella pneumoniae Resistance: A Five-Year Ecological Study in a Regional Hospital

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Discussion

Ecological study reveals significant correlation between antibiotic consumption and E. coli resistance rates, suggesting need for monitoring.

A significant correlation exists between doxycycline use and E. coli resistance to meropenem (r=0.894; p=0.041).
Cefoperazone consumption is very strongly correlated with E. coli resistance to ampicillin-sulbactam (r=0.952; p=0.012).
The study evaluated systemic antibiotic consumption data to analyze resistance in Escherichia coli and Klebsiella pneumoniae.
No significant correlation was found between antibiotic usage and resistance in Klebsiella pneumoniae, indicating other factors may be involved.

Sanjaya et al. (2025) studied this question.

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Ecological study reveals significant correlation between antibiotic consumption and E. coli resistance rates, suggesting need for monitoring.