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September 29, 2025Pest Management Science

Comprehensive genomic analysis and functional characterization of a new entomopathogenic strain, Bacillus thuringiensis subsp. israelensis VCRC B646, antagonistic to mosquito vectors (Diptera: Culicidae), isolated from soil in Tamil Nadu, India

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Authors

AVAbhisubesh VijayakumarMAMathivanan AshokumarBGBhavna Gupta

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Overview

This research shows that a new strain demonstrates potent larvicidal activity against mosquito vectors, indicating its potential for eco-friendly vector control.

Key Points

  • Bti VCRC B646 exhibited high larvicidal potency against Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus, with LC₉₀ values below 0.015 μg mL −1.
  • Whole-genome sequencing revealed a 6.6-Mbp genome with multiple plasmids, including those with insecticidal toxin genes and verified the identity as Bacillus thuringiensis.
  • Genomic features included the identification of toxin genes and secondary metabolite clusters, contributing to its ecological safety without major pathogenic markers.
  • The strain's efficacy and environmental safety suggest it could serve as a sustainable option for integrated vector management in public health.

Cite This Study

Vijayakumar et al. (2025) studied this question.

synapsesocial.com/papers/68da5a3ec1728099cfd11a3fhttps://doi.org/10.1002/ps.70236
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Also Consider

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  1. 1Comprehensive Evaluation of Bacillus thuringiensis subsp. israelensis: From Molecular Profiling to Ecotope-Specific Larvicidal Efficacy Against Laboratory Aedes aegypti and Wild Mosquito Populations2026
  2. 2Bacillus thuringiensis subsp. israelensis at the Public Health–Ecology–Biotechnology Nexus: From Larvicidal Precision to Protein Delivery Platform Potentials2026
  3. 3Variable gut <scp>pH</scp> as a potential mechanism of tolerance to <scp><i>Bacillus thuringiensis</i></scp> subsp. <scp><i>israelensis</i></scp> toxins in the biting midge <scp><i>Culicoides sonorensis</i></scp>2024 · 1 citations
  4. 4A New Aqueous Formulation from Indigenously Isolated Bacillus &lt;i&gt;Thuringiensis Israelensis&lt;/i&gt; VCRC B646 for Mosquito Control2024 · 1 citations
  5. 5Bacillus thuringiensis israelensis VCRC B650 culture filtrate useful for mosquito oviposition attractant and larvicidal action2024 · 7 citations