September 30, 2025European Journal of PediatricsOpen Access

Pediatric acute respiratory distress syndrome in children with type I - spinal muscular atrophy: a 12-year case series

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Authors

MPMarco PiastraUniversità Cattolica del Sacro Cuore GMGeremia Zito MarinosciRutgers, The State University of New Jersey AOA. Wayne OrrUniversità Cattolica del Sacro Cuore

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Implication

Retrospective case series reports survival rates in SMA-1 children with pediatric acute respiratory distress syndrome, highlighting treatment implications.

Key Points

Survival is achievable in SMA-1 children suffering from pediatric acute respiratory distress syndrome, with 83.3% surviving to discharge.
The median PaO2/FiO2 ratio for all patients was 95, with non-survivors at a significantly lower ratio of 67 (p = 0.0283).
Data was collected from 18 patients diagnosed with SMA-1 and pARDS over a 12-year period in a pediatric intensive care unit.
Current intensive pARDS protocols may be applied to SMA-1 children, challenging past beliefs about treatment futility.

Cite This Study

Piastra et al. (2025) studied this question.

synapsesocial.com/papers/68dbd404ba965bf4e5c5c3ca https://doi.org/10.1007/s00431-025-06464-3

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Implication

Retrospective case series reports survival rates in SMA-1 children with pediatric acute respiratory distress syndrome, highlighting treatment implications.

Pediatric acute respiratory distress syndrome in children with type I - spinal muscular atrophy: a 12-year case series

Discussion

Member takes

Implication

Key Points

Cite This Study

Pediatric acute respiratory distress syndrome in children with type I - spinal muscular atrophy: a 12-year case series

Discussion

Member takes

Implication

Key Points

Cite This Study

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