Metabolism‐Regulating Nanomedicines for Cancer Therapy

Cancer cells undergo significant metabolic reprogramming to meet their increased bioenergetic and biosynthetic needs, supporting rapid proliferation and survival. Key metabolic pathways, including those involved in glucose, lactate, amino acid, lipid, and nucleotide metabolism, are altered to facilitate cancer development, maintenance, and metastasis. Therefore, targeting cancer metabolism emerges as a promising therapeutic strategy. However, because of their short half‐life, limited bioavailability, and inadequate specificity in metabolic regulation, these agents often result in unsatisfactory therapeutic outcomes. Recently, innovative nanomedicines that target metabolic processes have gained attention as a promising cancer therapy strategy, potentially helping to overcome the limitations of individual therapies and enhance treatment efficacy. This review provides an overview of tumor metabolic characteristics and explores recent progress in developing functional nanomedicines targeting tumor metabolism for cancer treatment. Finally, this review discusses the challenges and prospects for advancing nanotechnology‐driven metabolic therapies.