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September 30, 2025Open Access

Role and mechanism of palmitic acid-regulated palmitoylation modification of SEC63 protein during endoplasmic reticulum stress in Human Ovarian Granulosa Tumor Cells (KGN)

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Authors

YMYalan MaZJZhenzhen JinAYAijun Yang

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Overview

This analysis reveals how palmitic acid affects SEC63 palmitoylation during ER stress in ovarian granulosa tumors, enhancing oxidative stress markers.

Key Points

  • Palmitic acid increases oxidative stress and ER stress markers in KGN cells.
  • In a mouse model, PA induced polycystic ovarian morphology and dysregulated hormone levels.
  • SEC63 was identified as a key protein modified by palmitoylation, impacting stress responses.
  • Lipoic acid and SEC63 modulation may hold therapeutic potential against PA-induced ovarian dysfunction.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e308a7d58c25ebb1470https://doi.org/10.21203/rs.3.rs-7512566/v1
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