The effect of rivaroxaban and dabigatran on glycaemic parameters and lipid profile in high-fat diet and low-dose streptozotocin-induced diabetes mellitus in male Wistar rats

Objectives: The experimental study evaluated the effect of rivaroxaban and dabigatran on glycaemic parameters in a high-fat diet (HFD) and low-dose streptozotocin (STZ)-induced diabetes mellitus in male Wistar rats. In addition, the effect on the lipid profile and inflammatory markers was also assessed. Materials and Methods: There was one normal control group, while others consisted of diabetic rats without treatment or with treatment. Diabetes was induced by feeding the rats with HFD for 2 weeks, followed by a single intraperitoneal injection of STZ. Following that treatment with either metformin (MF), rivaroxaban or dabigatran, and was continued for 6 weeks. Body weight, fasting blood glucose (FBG) and lipid profile were measured at various time intervals. Inflammatory markers were studied at the end of the study. Results: All three treatments significantly reduced FBG compared to the untreated rats. In addition, they showed improvement in body weight as well as lipid profile. The inflammatory markers (Interleukin [IL]-1b, IL-6, tumour necrosis factor alpha) were significantly reduced in all treatment groups as compared to untreated rats. Conclusion: The present study showed that the treatment of diabetic rats with rivaroxaban and Dabigatran improved the HFD and STZ-induced biochemical alterations.