Systematic review highlights the impact of magnesium deficiency on alcohol-related liver disease, suggesting its potential role in disease progression.
Magnesium is necessary for the proper function of various enzymes involved in cellular activity. The liver plays a crucial role in maintaining macro- and micronutrient homeostasis in the body. Magnesium deficiency is associated with alcohol-related liver disease (ALD) and the progression of chronic liver disease. Magnesium may also impact other factors and markers associated with liver disease. We hypothesize that magnesium deficiency may exacerbate alcoholism to ALD. This systematic analysis on the effects of magnesium on liver health involved a literature search using electronic databases up to June 2024. Review included studies on the role of magnesium in the progression of ALD in both animals and humans. Outcome of selected studies meeting the eligibility criteria were tabulated and discussed narratively. In order to investigate intracellular magnesium activity under deficiency conditions during the progression of ALD. Reduced magnesium levels have been shown in patients with alcohol-related cirrhosis, revealing significant homogeneity via a random effects model (p < .001). In patients with end-stage liver disease due to increased alcohol intake, impaired magnesium regulation contributes to disease progression and reduced quality of life. Whereas magnesium supplementation might help prevent complications, however, it is needed to confirm its safety and efficacy in view of therapeutic approach.
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Prabhudas Nelaturi (2025) studied this question.
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