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This is a Experimental Study study.

September 30, 2025Cancer ScienceOpen Access

Activation of cGAS‐STING Pathway by DAI‐Triggered Ferroptosis in CRC Cells Reprograms TAMs Balance to Promote Anti‐Tumor Immunity

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Activation of the cGAS-STING pathway enhances M1 polarization of TAMs in CRC, suggesting immunotherapeutic potential.

DAI-driven ferroptosis significantly reduced tumor size and weight in mouse CRC models, enhancing anti-tumor effects.
Activation of the cGAS-STING pathway through mtDNA release from stressed mitochondria was a key mechanism observed.
DAI also reprogrammed the tumor immune microenvironment by promoting M1 polarization of TAMs while inhibiting M2 polarization.
These findings highlight the potential of targeting ferroptosis and the cGAS-STING pathway in CRC therapies.

Cheng et al. (2025) studied this question.

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