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September 30, 2025Safety and Risk of PharmacotherapyOpen Access

Therapeutic Potential of Myo-Inositol in Male Infertility: Correction of Spermatogenesis Parameters and Oxidative Stress (Review)

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Authors

SGS. M. GiulakhmedovaADA. A. DruzhininaOAO. S. Alyautdina

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Overview

Review examines how myo-inositol improves spermatogenesis and reduces oxidative stress in various infertility types.

Key Points

  • Myo-inositol improves sperm motility by 20-30% and progressive motility by up to 40%, indicating its potential in male infertility treatment.
  • Sperm quality improved with myo-inositol reduces oxidative damage markers and DNA fragmentation by 3-5%, supporting its therapeutic role.
  • The review discusses myo-inositol's antioxidant properties, boosting mitochondrial metabolism and ATP production in sperm.
  • Large controlled trials are necessary to confirm myo-inositol's efficacy in restoring male reproductive function across various aetiologies.

Cite This Study

Giulakhmedova et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e3f8a7d58c25ebb2097https://doi.org/10.30895/2312-7821-2025-13-3-290-299
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