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September 30, 2025

Mycobacterium tuberculosis antigen containing-exosomes reinforce BCG vaccine efficacy by augmenting long term protection and memory response against experimental tuberculosis in BALB-C mice.

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Research shows exosomes boost immune responses and memory in mice, suggesting new strategies for tuberculosis prevention.

Exosomes enhance BCG vaccine efficacy by boosting immune responses against mycobacterium tuberculosis.
The study found increased CD4⁺ and CD8⁺ T cells and memory T-cell populations in mice receiving exosomes.
Exosome treatment significantly reduced mycobacterium tuberculosis load in lungs, spleen, and lymph nodes.
MPE demonstrates potential as a promising booster strategy for people vaccinated with the BCG vaccine.

Sharma et al. (2025) studied this question.

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