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This is a Quantitative Study study.

September 30, 2025Bioinformatics AdvancesOpen Access

Deconvolution and Phylogeny Inference of Diverse Variant Types Integrating Bulk DNA-seq with Single-cell RNA-seq

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Integration of bulk DNA-seq and single-cell RNA-seq improves clonal resolution, highlighting mutant histories.

Improved deconvolution performance enhances understanding of tumor phylogenetics and variant types.
Utilization of integer linear programming enables effective reconstruction of clonal lineage trees.
Integration of different sequencing types addresses limitations in standard RNA-seq and DNA-seq approaches.
Application on a breast cancer dataset demonstrates the ability to resolve structural variations effectively.

Bristy et al. (2025) studied this question.

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