[Ph3C][B(C6F5)4]-catalyzed aza-Michael-type reaction of vinylpyridines with primary/secondary amines

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This is a Experimental Study study.

Weiming Zhu; Zhi-Xiong Deng; Yaorong Wang; Dan Yuan; Yingming Yao

doi:10.1039/d5nj00014a

January 1, 2025New Journal of Chemistry

[Ph3C][B(C6F5)4]-catalyzed aza-Michael-type reaction of vinylpyridines with primary/secondary amines

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Key Points

The reaction shows improved efficiency and broader substrate scope, highlighting a new method for synthesizing functionalized compounds.
Utilizing the catalyst [Ph3C][B(C6F5)4], this reaction operates effectively with various aliphatic and aromatic primary and secondary amines.
The developed protocol showcases the ease of access to a non-metal catalyst while enhancing yields of the desired aza-Michael products.
This method indicates a significant advancement in catalysis by broadening the applicability of aza-Michael-type reactions with amines.

Implication

A novel aza-Michael reaction improves yields in vinylpyridines with primary and secondary amines, suggesting a non-metal catalytic approach.

Abstract

Aza-Michael-type reaction of vinylpyridines with amines catalyzed by easily available and non-metal catalyst [Ph3C][B(C6F5)4] has been developed. This protocol is applicable to a broad range of aliphatic and aromatic primary/secondary...

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Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68dc26188a7d58c25ebb28b8 https://doi.org/10.1039/d5nj00014a

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[Ph3C][B(C6F5)4]-catalyzed aza-Michael-type reaction of vinylpyridines with primary/secondary amines

Key Points

Implication

Abstract

Discussion

Cite This Study

[Ph3C][B(C6F5)4]-catalyzed aza-Michael-type reaction of vinylpyridines with primary/secondary amines

Key Points

Implication

Abstract

Discussion

Cite This Study

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