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September 30, 2025CellsOpen Access

Myocardial Ischemia/Reperfusion Injury: Molecular Insights, Forensic Perspectives, and Therapeutic Horizons

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Authors

MFMaria Sofia FedeGDGloria DazianiFTFrancesco Tavoletta

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Overview

This review reveals mechanisms of myocardial ischemia/reperfusion injury, highlighting inflammatory responses and therapeutic strategies.

Key Points

  • MIRI exacerbates infarct size, negatively impacting outcomes after acute myocardial infarction.
  • Findings from autopsy cases show how successful reperfusion does not prevent delayed complications from MIRI.
  • Review includes the role of specific inflammatory mechanisms such as the NLRP3 inflammasome in MIRI.
  • Immunotherapeutic strategies targeting cytokines may help reduce cardiovascular events related to MIRI.

Cite This Study

Fede et al. (2025) studied this question.

synapsesocial.com/papers/68dc261d8a7d58c25ebb2a83https://doi.org/10.3390/cells14191509
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