Modular and Diverse Synthesis of Oxaheterocycles via Pd-Catalyzed Migratory 1,n-Cycloannulation of Alkenes

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This is a Experimental Study study.

Jinping Wang; Yi‐Chen Wu; Peng Wang

doi:10.1039/d5sc06539a

January 1, 2025Chemical ScienceOpen Access

Modular and Diverse Synthesis of Oxaheterocycles via Pd-Catalyzed Migratory 1,n-Cycloannulation of Alkenes

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Key Points

The modular synthesis strategy allows for the creation of various oxaheterocycles efficiently through a Pd-catalyzed method.
Utilizing alkenes as substrates has demonstrated strong versatility leading to multiple products with distinct functional groups.
The migratory 1,n-cycloannulation reaction method shows promise for further applications in organic synthesis and pharmaceutical development.
This approach's efficiency relies on readily available (homo)allylphenols and has implications for expanding synthetic avenues.

Implication

This strategy demonstrates Pd-catalyzed migratory 1,n-cycloannulation, enabling diverse oxaheterocycle synthesis from alkenes.

Abstract

Here, we report a general and modular strategy for the diverse synthesis of oxaheterocycles via a Pd-catalyzed migratory 1,n-cycloannulation reaction (MCAR, n > 2) of alkenes. Employing readily available (homo)allylphenols...

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68dc261d8a7d58c25ebb2b34 https://doi.org/10.1039/d5sc06539a

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Modular and Diverse Synthesis of Oxaheterocycles via Pd-Catalyzed Migratory 1,n-Cycloannulation of Alkenes

Key Points

Implication

Abstract

Discussion

Cite This Study

Modular and Diverse Synthesis of Oxaheterocycles via Pd-Catalyzed Migratory 1,n-Cycloannulation of Alkenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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