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September 30, 2025International Journal of Environmental Sciences

Synthesis And Characterization Of Novel Of 1, 3, 4-Thiadiazole Derivatives As Potential Α-Amylase Inhibitor

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Authors

DKDeepak KadamVPVinayak PawarBDBhagyashree Ramdas Dhambore

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Overview

Novel 1,3,4-thiadiazole derivatives show effective α-amylase inhibition in-vitro, suggesting potential for diabetes management.

Key Points

  • Compound A8 showed the highest α-amylase inhibitory activity with an IC50 value of 44.67 µg/mL, exceeding Acarbose.
  • Molecular docking revealed compound A8 had a binding affinity score of -9.5 kcal/mol with α-amylase.
  • The synthesis yielded moderate to high efficiencies (67-93%), confirmed by various characterization techniques.
  • Favorable pharmacokinetic properties were observed for most compounds, indicating potential efficacy and safety in diabetes treatment.

Cite This Study

Kadam et al. (2025) studied this question.

synapsesocial.com/papers/68dc26218a7d58c25ebb2d09https://doi.org/10.64252/9edv6k57
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