What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

September 30, 2025Annals of MedicineOpen Access

Withholding vs. continuing angiotensin-converting enzyme inhibitors or angiotensin receptor blockers before surgery: a systematic review and meta-analysis of randomized controlled trials

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Systematic review finds withholding ACEIs/ARBs reduces intraoperative hypotension, suggesting implications for surgical management.

Withholding ACEIs/ARBs before surgery led to a 26% reduction in intraoperative hypotension compared to continuing therapy.
The meta-analysis included 14 randomized controlled trials, assessing outcomes in over 4000 patients undergoing surgery.
Withholding therapy resulted in a mean reduction of 5.41 minutes in duration of hypotension and decreased vasopressor use.
Low confidence in evidence points to the need for further research on the clinical significance of these findings.

Dou et al. (2025) studied this question.

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