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September 30, 2025Neurochemical ResearchOpen Access

Hesperidin Attenuates Chronic Stress-Induced Depression via 5-HT2A-Linked Modulation of Neurochemical, Oxidative, and Inflammatory Pathways: Experimental and In Silico Evidence

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Authors

MKMimansa Kandhwal AGAmarjot Kaur Grewal VSVarinder Singh

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Overview

Animal study shows hesperidin improves depression-related outcomes in mice with chronic stress, suggesting neuroprotective mechanisms linked to 5-HT2A modulation.

Key Points

Hesperidin treatment significantly improved depressive-like behaviors and neurochemical alterations in mice with chronic stress, indicating its potential as an antidepressant.
The study reported restored levels of serotonin and dopamine, along with reduced oxidative stress and inflammation markers, highlighting hesperidin's multifaceted effects.
Molecular dynamics simulations demonstrated the stable binding of hesperidin to 5-HT2A receptors, confirming its mechanism of action against chronic stress-induced neurochemical changes.
These findings suggest hesperidin could be an effective therapeutic agent for depression, but further research in humans is necessary.

Cite This Study

Kandhwal et al. (2025) studied this question.

synapsesocial.com/papers/68dc26268a7d58c25ebb3263 https://doi.org/10.1007/s11064-025-04562-0

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September 30, 2025Neurochemical ResearchOpen Access

Hesperidin Attenuates Chronic Stress-Induced Depression via 5-HT2A-Linked Modulation of Neurochemical, Oxidative, and Inflammatory Pathways: Experimental and In Silico Evidence

View Full Paper

Ask AI

Bookmark

Authors

MKMimansa Kandhwal AGAmarjot Kaur Grewal VSVarinder Singh

Discussion

Member takes

Overview

Animal study shows hesperidin improves depression-related outcomes in mice with chronic stress, suggesting neuroprotective mechanisms linked to 5-HT2A modulation.

Key Points

Hesperidin treatment significantly improved depressive-like behaviors and neurochemical alterations in mice with chronic stress, indicating its potential as an antidepressant.
The study reported restored levels of serotonin and dopamine, along with reduced oxidative stress and inflammation markers, highlighting hesperidin's multifaceted effects.
Molecular dynamics simulations demonstrated the stable binding of hesperidin to 5-HT2A receptors, confirming its mechanism of action against chronic stress-induced neurochemical changes.
These findings suggest hesperidin could be an effective therapeutic agent for depression, but further research in humans is necessary.

Cite This Study

Kandhwal et al. (2025) studied this question.

synapsesocial.com/papers/68dc26268a7d58c25ebb3263 https://doi.org/10.1007/s11064-025-04562-0

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