An Overview of contrast Induce Acute kidney injury

The risk of contrast induced Acute kidney injury (CI-AKI) is high in CKD & diabetic patient as compared to general population. It is the third most cause of Hospital acquired AKI. Pathogenesis is not clear but there is role of direct & indirect cytotoxicity of contrast media, oxidative stress & as well as of micro-RNA. There is no specific therapy of CI-AKI, hence prevention is the cornerstone of management. Except hydration therapy all other pharmacotherapy has been failed to prove beneficial effect in preventing CI-AKI in many RCT & meta-analyses.