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The Gender Gap in Life Expectancy in the United States and Deaths of Despair: Trends From 1979 to 2022

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The resurgence in women's life expectancy advantage is closely linked to an increase in deaths of despair among men.
From 2012 onward, deaths of despair became the dominant factor in explaining women's improved life expectancy compared to men.
Trends show that drug-related mortality has a particularly high impact on life expectancy gaps among lower-educated groups.
Long-term data indicates that deaths of despair have hindered the expected equalization of the gender gap since 1979.

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Analysis reveals deaths of despair significantly impact life expectancy in men and women, highlighting trends over decades.

González‐Velastín et al. (2025) studied this question.

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