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October 1, 2025Alzheimer s & DementiaOpen Access

Plasma p‐tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic

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Authors

DEDhamidhu EratneMKMatthew KangCMCharles B. Malpas

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Overview

Prospective study assesses plasma biomarkers in Alzheimer's disease and frontotemporal dementia, indicating their utility in distinguishing from psychiatric disorders.

Key Points

  • Plasma p‐tau217 distinguished Alzheimer's disease from frontotemporal dementia with 96% accuracy.
  • NfL effectively differentiated neurodegenerative disorders from psychiatric conditions in the cohort.
  • Blood-based biomarkers offer strong diagnostic potential in complex memory clinic settings.
  • Elevated p‐tau217 in Alzheimer's compared to other disorders underscores its diagnostic relevance.

Cite This Study

Eratne et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497d8fhttps://doi.org/10.1002/alz.70717
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