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October 1, 2025Perioperative Precision MedicineOpen Access

Unlocking the therapeutic potential of disulfiram in sepsis: Mechanisms and future directions

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Authors

QWQi WuWJWentao JiXZXiaoting Zhang

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Overview

Review reveals disulfiram's immune-regulatory effects on sepsis, suggesting future studies could explore its therapeutic potential.

Key Points

  • Disulfiram may be repurposed as a treatment for sepsis, potentially reducing pyroptosis and inflammasome activation.
  • Current evidence is limited, indicating a need for more precise clinical approaches to validate disulfiram's effectiveness.
  • Research should systematically assess disulfiram’s immune-regulatory capabilities in the context of sepsis management.
  • The review aims to highlight disulfiram’s value and streamline future research directions in sepsis treatment.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497dcdhttps://doi.org/10.61189/588589vgwoub
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