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October 1, 2025

Neuropilin-2 Mediates Radioresistance in Nasopharyngeal Carcinoma via Wnt/β-Catenin Pathway.

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Authors

JCJ X ChenHainan General HospitalHFHuimin FuSouthwest UniversityXHXiaopeng HuangHainan General Hospital

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Implication

Analysis reveals neuropilin-2 mediates radiation resistance in nasopharyngeal carcinoma, indicating Wnt/β-catenin signaling's involvement.

Key Points

  • NRP2 knockdown significantly reduced cell proliferation and colony formation after radiation exposure.
  • Expression of NRP2 was notably higher in nasopharyngeal carcinoma tissues than normal tissues.
  • Bioinformatics analyses showed the Wnt/β-catenin pathway is enhanced in nasopharyngeal carcinoma.
  • Targeting NRP2 may offer a new therapeutic approach in managing radioresistance in nasopharyngeal carcinoma.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497ecchttps://doi.org/10.2147/cmar.s536248
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