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October 1, 2025Journal of Indian Academy of Oral Medicine and RadiologyOpen Access

A Preliminary Clinicopathologic Study to Evaluate the Association of Human Papilloma Virus in Oral Squamous Cell Carcinoma and Its Influence on Prognostic Significance

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Authors

ACA. Winnifred ChristyUSUma SudhakarSRSnophia Rani Rajamani

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Overview

Observational study explores human papilloma virus role in oral squamous cell carcinoma survival, suggesting prognostic significance.

Key Points

  • HPV may be associated with oral squamous cell carcinoma, indicating its potential role in cancer development.
  • In this study, 14 out of 51 patients showed overexpression of p16, which is linked to HPV presence.
  • Patients with p16 overexpression had slightly improved disease free survival compared to those without.
  • Overall survival was also marginally higher in p16 positive patients, suggesting a potential prognostic advantage.

Cite This Study

Christy et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc498650https://doi.org/10.4103/jiaomr.jiaomr_135_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Significance of Human Papillomavirus DNA Test and p16 Overexpression in Oropharyngeal Cancer2024
  2. 2p16 overexpression identifies oncogenic <scp>high‐risk HPV</scp> infection in <scp>non‐oropharyngeal</scp> squamous cell carcinoma of the head and neck2024 · 7 citations
  3. 3HPV and p16 expression association with 5-year survival in oral squamous cell carcinoma patients of north-east India2024 · 3 citations
  4. 4Association of HPV16 infection with p53 and survivin expression in oral squamous cell carcinoma2026
  5. 5Prevalence of HPV in Oral Squamous Cell Carcinoma Through p16 IHC: A Hospital-Based Study in Eastern India2024 · 3 citations