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Drug repurposing approach for the discovery of therapeutic agents for Crohn’s disease-associated intestinal fibrosis

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Meta-regression analysis of gene expression in fibroblasts identifies key targets and compounds, indicating potential anti-fibrotic therapies.

Potential anti-fibrotic compounds were identified, showing promise in reversing gene expression related to intestinal fibrosis.
The study highlighted the importance of IL-6 and fibroblast activation protein as druggable targets with key involvement in the fibrotic process.
Drug repurposing platforms were utilized to screen over 6,700 compounds, revealing PI3K inhibitors and histone deacetylase blockers as effective candidates.
Evaluation of compounds was conducted in vitro using fibroblasts from patients, supporting their therapeutic potential in Crohn's disease.

Nikolakis et al. (2025) studied this question.

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Meta-regression analysis of gene expression in fibroblasts identifies key targets and compounds, indicating potential anti-fibrotic therapies.