October 1, 2025Tropical Journal of Natural Product ResearchOpen Access

Integrative Network Pharmacology and Molecular Docking Analysis of Uncaria gambir Roxb. Against MCF-7 Human Breast Cancer Cells

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NHNur HasanahUniversitas Widya Dharma Klaten NYNanang YunartoUniversity of Indonesia NINurwulan Adi IsmayaSurya University

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Implication

This study demonstrates network pharmacology and molecular docking assessing uncaria gambir against MCF-7 breast cancer, highlighting its multi-target capabilities.

Key Points

Uncaria gambir showed potential as an anti-cancer agent against MCF-7 breast cancer cells, with compounds like catechin and quercetin identified.
Molecular docking revealed strong affinities to target genes such as TP53 and ESR1, with binding energies ranging from -7.2 to -8.9 kcal/mol.
Active compounds were screened based on pharmacokinetic parameters, confirming their appropriate bioavailability and safety profiles.
The findings indicate that uncaria gambir could serve as a valuable source for multi-target treatments in breast cancer therapy.

Cite This Study

Hasanah et al. (2025) studied this question.

synapsesocial.com/papers/68dd91cbfe798ba2fc4988bc https://doi.org/10.26538/tjnpr/v9i9.44

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Implication

This study demonstrates network pharmacology and molecular docking assessing uncaria gambir against MCF-7 breast cancer, highlighting its multi-target capabilities.

Integrative Network Pharmacology and Molecular Docking Analysis of Uncaria gambir Roxb. Against MCF-7 Human Breast Cancer Cells

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Implication

Key Points

Cite This Study

Integrative Network Pharmacology and Molecular Docking Analysis of Uncaria gambir Roxb. Against MCF-7 Human Breast Cancer Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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