Resveratrol Enhances Paclitaxel and Doxorubicin to Inhibit Human Adenocarcinoma (A549) Cells Proliferation through Wnt Pathway

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Laboratory analysis shows resveratrol enhances chemotherapy effects in lung cancer cells, indicating better treatment options.

Resveratrol significantly inhibits A549 lung cancer cell proliferation and enhances the effects of paclitaxel.
A dose-dependent reduction in beta-catenin and TCF-4 mRNA expression was observed with resveratrol and paclitaxel.
The study employs various assays, including proliferation and wound healing assays, to explore cell growth effects.
These findings suggest that using resveratrol alongside chemotherapy could mitigate severe side effects from treatment.

Tsao et al. (2025) studied this question.

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