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October 1, 2025PLoS BiologyOpen Access

Plasma membrane recycling drives reservoir formation during Toxoplasma gondii intracellular replication

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Research uncovers how plasma membrane recycling influences reservoir formation in Toxoplasma gondii, suggesting endocytosis is critical.

The study reveals that plasma membrane recycling is essential for the formation of plasma membrane reservoirs during Toxoplasma gondii replication.
Key proteins like Rab5b and MyoF regulate the dynamics of plasma membrane recycling and its association with parasites' intracellular development.
Analysis indicates that micropores play a significant role in maintaining plasma membrane homeostasis, impacting the stability of membrane organization.
Disruption of the endo-exocytic balance leads to altered plasma membrane reservoir formation, emphasizing the connection to endocytosis.

Knoerzer-Suckow et al. (2025) studied this question.

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