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This is a Systematic Review study.

Immune Activation in Primary Sclerosing Cholangitis: A Systematic Review and Comparative Analysis With Inflammatory Bowel Diseases

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Immune activation patterns can distinguish patients with primary sclerosing cholangitis from those with inflammatory bowel disease.
Patients with primary sclerosing cholangitis showed increased levels of Th17 cells and decreased Tregs in circulation compared to controls.
Systematic review analyzed 23 articles involving 638 primary sclerosing cholangitis patients and 557 inflammatory bowel disease subjects.
Findings suggest unique immune profiles between primary sclerosing cholangitis and inflammatory bowel disease that may influence treatment approaches.

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Systematic review compares immune activation in primary sclerosing cholangitis and inflammatory bowel disease, highlighting significant differences.

Moniruzzaman et al. (2025) studied this question.

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Systematic review compares immune activation in primary sclerosing cholangitis and inflammatory bowel disease, highlighting significant differences.