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October 1, 2025NutrientsOpen Access

Melatonin and Vitamins: A Promising Combination to Augment Conventional Anticancer Therapies

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Authors

WTWamidh H. TalibSSSiham SabriRHRawan W. Hadi

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Overview

This review demonstrates the potential benefits of melatonin and vitamins in cancer treatment, suggesting promising avenues for integrative oncology.

Key Points

  • Combining melatonin with vitamins may improve tumor suppression and reduce treatment toxicity, enhancing patient outcomes.
  • Emerging evidence highlights melatonin's role in regulating oxidative stress and apoptosis, along with vitamins D, C, and E's protective benefits.
  • Despite promising preclinical findings, clinical studies on the synergy of melatonin and vitamins remain limited, indicating a need for further investigation.
  • Future research should explore optimal dosing, mechanistic insights, and conduct clinical trials to establish the efficacy of these combinations.

Cite This Study

Talib et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc498f43https://doi.org/10.3390/nu17193120
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Also Consider

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  1. 1Melatonin and Selected Phytochemicals: A Promising Combination to Target Altered Metabolism in Cancer2026 · 1 citations
  2. 2Melatonin and Virus induced Oncogenic Factors2025
  3. 3Melatonin in Integrative Oncology: Biological Mechanisms, Therapeutic Evidence and Implementation Strategies2026 · 2 citations
  4. 4Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery Approaches2026
  5. 5Melatonin at the Crossroads of Oxidative Stress, Immunity, and Cancer Therapy2026 · 7 citations