Clinical and radiological assessment of grape seed extract versus mineral trioxide aggregates in primary molar pulpotomy: A randomized controlled clinical trial

Background: This study aimed to assess the radiological and clinical outcomes of mineral trioxide aggregates (MTA) versus grape seed extract (GSE) when used as a dressing material in primary teeth undergoing pulpotomy. Methods: This was a prospective split-mouth randomized clinical study. A total of 32 primary teeth were included and split into 2 groups: MTA was used in group I, and GSE was used in group II. A clinical and radiographic follow-up was conducted for 6 months postoperatively. Periapical radiographs were taken for all treated teeth at 3- and 6-month follow-up visits. Radiographic criteria for clinical success included absence of internal resorption, pathologic external resorption, interradicular radiolucency, periapical radiolucency, and widening of the periodontal ligament space. Result: In the MTA group, clinical and radiographic success was 100% at 1 and 3 months, in comparison to 93.75% 6 months postoperatively. In the GSE group, clinical success was 100% 1 month, and 93.75% 3 and 6 months postoperatively, while radiographic success was 100% at 3 months, 87.5% 6 months postoperatively. There were no significant statistical differences in the overall clinical or radiographic outcomes between the study groups ( P > .05). Conclusion: Both MTA and GSE are associated with successful clinical and radiographic outcomes of pulpotomy; however, MTA seems to be associated with reduced inflammatory reactions, rendering it more effective than GSE.