Structured skin care for a patient with toxic epidermal necrolysis caused by anlotinib: Case report

Rationale: Toxic epidermal necrolysis is a life-threatening disease. Over 95% of toxic epidermal necrolysis cases are caused by drugs, presenting as hemorrhagic erythema, blisters, and extensive epidermal detachment on the skin and mucous membranes. It is usually accompanied by multiple system damage. According to the size of the exfoliated area, toxic epidermal necrolysis is classified as severe (exfoliation area >30% of body surface area). Patient concerns: A 78-year-old female patient was admitted to our Department of Medical Oncology due to “after pancreatic cancer surgery for >9 months, discovery of liver metastasis for >1 months, multiple oral ulcers accompanied by multiple rashes throughout the body, with large red exfoliative maculopapule on the hands and feet for 5 days.” Diagnoses: Postoperative status of pancreatic cancer, liver metastasis, and toxic epidermal necrolysis. Interventions: After discontinuing anlotinib, the skin symptoms did not subside. Therefore, structured skin care was started. Outcomes: The skin symptoms was resolved after starting structured skin care. Lessons: In this case, there was only 1 patient, and the nursing care was relatively limited. The effect needs further verification.