Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 2025I P Pavlov Russian Medical Biological Herald

Changes in the amount of matrix metalloproteinases and kynurenines in individuals with diabetic retinopathy, their role in the development of the disease

View Full Paper
Ask AI
Bookmark
Share

Authors

ОSО. A. SaklakovaMMM. V. MaksimenyaТКТ. М. Караваева

Discussion

Loading...

Member takes

Overview

Observational analysis reveals altered matrix metalloproteinases and kynurenines in diabetic retinopathy patients, indicating their potential role in disease severity.

Key Points

  • Significant increases in MMP-2 and MMP-9 levels were observed in patients with diabetic retinopathy compared to healthy individuals.
  • Patients with proliferative diabetic retinopathy had higher concentrations of MMP-9 and MMP-2 than those with non-proliferative stages.
  • Kynurenines showed a marked increase with the progression of diabetic retinopathy, particularly in later stages.
  • The study suggests that monitoring MMPs and kynurenines may help assess the severity of diabetic retinopathy in patients.

Cite This Study

Saklakova et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc4996f3https://doi.org/10.17816/pavlovj627167
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation between molecules, which reflect malfunctioning of cellular respiration, degree of oxidative stress, and glycated hemoglobin in retinopaties with type 2 diabetes2024
  2. 2Plasma matrix metalloproteinases and tissue inhibitors of metalloproteinases explored in relation to the severity and progression of diabetic retinopathy in patients with type 1 diabetes: baseline and prospective analyses2024 · 2 citations
  3. 3Changes in the level of some tryptophan metabolites in the blood of patients with type 2 diabetes mellitus complicated by diabetic retinopathy2024 · 1 citations
  4. 4The Role of ADAM9 and MMP9 in Diabetic Retinopathy: Insights from Ocular Parameters2025
  5. 5Matrix metalloproteinases in patients with resistant hypertension and type 2 diabetes mellitus: relation with renal blood flow and kidney function2019 · 5 citations