Co-culture of endophytic fungi produces cytochalasans, revealing antifungal properties against Fusarium.
A new cytochalasan, sophochalasin (1), together with ten known analogous compounds were obtained from the co-culture of two endophytic fungi Aspergillus spelaeus and Xylaria sp. The structure and the absolute configuration of 1 were established via NMR and ECD spectral analysis. In antifungal assay, aspochalasin B (2) exhibited notable antifungal activity against Fusarium oxysporum, Colletotrichum siamense, Alternaria alternata and Fusarium oxysporium f. sp. cucumberinum with MICs of 16 μg/mL.
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He et al. (2025) studied this question.
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