This approach demonstrates efficient Lewis acid-catalyzed transformations, achieving yields up to 94% in various substrates.
Herein, we introduce an innovative approach employing a direct visible-light-excited Lewis acid-catalyzed [2σ + 3π] cycloaddition reaction between bicyclo[1.1.0]butanes and α-vinyl azides via diradical intermediate. This transformation proceeds efficiently in the absence of any external photocatalyst produces versatile 2-azabicyclo[3.1.1]heptene derivatives with a broad substrate scope, achieving yields of up to 94% across 34 examples. The synthetic practicality was further demonstrated through a scaled-up reaction, and the transformation of the imidazole auxiliary into an ester group.
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Du et al. (2025) studied this question.
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