Disseminated eczema or CTCL: Usefulness of high-frequency ultrasonography in the assessment of skin lesions of cutaneous T-cell lymphoma

Cutaneous T-cell lymphoma (CTCL) presents a diagnostic and prognostic challenge in evaluating disease progression. High-frequency ultrasound (HFUS) is a non-invasive imaging technique that has emerged as a valuable tool for assessing dermal alterations, including infiltrative intensity in CTCL. Herein, we report the case of a 74-year-old male patient with a long-standing history of neurofibromatosis type 1 (NF1) since childhood who was also diagnosed with Sézary syndrome (SS) and whose disease remission was confirmed through HFUS examination during PUVA and methotrexate therapy. HFUS facilitated the assessment of infiltrative intensity, visualization of tumor characteristics, and monitoring of disease progression and treatment response. The high-resolution imaging provided by HFUS gave detailed and precise information about the affected skin layers, contributing to the diagnostic process and aiding in the management of CTCL.