Case report highlights the link between cocaine use and squamous cell carcinoma in morphea patients, suggesting a need for further investigation.
Localized cutaneous scleroderma, or morphea, is a highly heterogeneous group of autoimmune disorders that primarily affect the skin and adjacent tissues. Its pathogenesis remains unclear. Numerous factors, including genetics, drugs, infections, skin injuries, autoimmune diseases with abnormal cytokine production and/or such as vascular dysfunction, may play a role in the development of morphea. Fibrosis, inflammation, and chronic ulceration may ultimately contribute to skin neoplasia. Herein, we report a case of multiple metastatic squamous cell carcinomas complicating cocaine-induced morphea.
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Hashas et al. (2024) studied this question.
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