Position of systemic therapy in the treatment of lichen pigmentosus

Background: : Lichen plan pigmentosus (LPP) is a cosmetically distressing pigmentation disorder that is often challenging to treat. Despite the limited availability of effective therapeutic options, tranexamic acid (TXA) and oral retinoids have emerged as promising treatments. This study evaluates the efficacy and safety of TXA and/or oral retinoids in patients with LPP. Materials and Methods: : We included 39 patients, with predominant sun exposure. Patients were treated locally with topical agents, and some received laser therapy. Systemic treatments (TXA and/or oral retinoids) were administered to certain patients, and therapeutic outcomes were assessed. Results: Moderate to good improvements were observed in more than half of the patients, particularly those treated with combined low-dose retinoids and TXA. The side effects were minor and did not require treatment discontinuation. Conclusion: This study, suggests that TXA and oral retinoids could be effective treatments for LPP. However, larger trials are needed to confirm these findings and improve treatment options for this condition.