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October 2, 2025International Journal for Research in Applied Science and Engineering TechnologyOpen Access

Inhibition of Quorum Sensing and Biofilm Formation in Pathogenic Bacteria by Euphorbiaceae-Derived Phytochemicals Purified Through Column Chromatography

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Authors

ATAshutosh TiwariATAmit Kumar Tiwari

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Overview

Laboratory analysis found that Euphorbiaceae compounds reduce quorum sensing and biofilm production in common pathogens, suggesting new strategies against antimicrobial resistance.

Key Points

  • Euphorbiaceae-derived phytochemicals significantly disrupted biofilm formation in Pseudomonas aeruginosa and other pathogens, reducing it by up to 70%.
  • Fraction analysis revealed that flavonoids and terpenoids diminished violacein production, showing potential to interfere with bacterial communication.
  • Thin-layer chromatography and HPLC were used to identify active components, focusing on compounds from Euphorbia Herta and Phyllanthus amarus.
  • Highlighting the promise of phytochemicals, these results indicate a potential avenue for developing natural antimicrobial strategies against resistant infections.

Cite This Study

Tiwari et al. (2025) studied this question.

synapsesocial.com/papers/68de5d9c83cbc991d0a2031bhttps://doi.org/10.22214/ijraset.2025.74422
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Also Consider

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  5. 5Targeting QS-mediated virulence in <i>Staphylococcus aureus</i> using <i>Eucalyptus globulus</i> essential oil: from chemistry to molecular docking2026 · 1 citations