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June 4, 2026Environmental Microbiology ReportsOpen Access

Modulation of Quorum Sensing and Virulence Gene Expression in Escherichia coli by Extracts of Physalis alkekengi

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Authors

MDMansoureh Esfandiyari DoolabyMMMohammad Javad Mehdipour MoghaddamANAkbar Norastehnia

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Overview

Randomized trial examines the effects of Physalis alkekengi extracts on virulence in uropathogenic E. coli, suggesting a potential treatment approach.

Key Points

  • This research aims to evaluate the effects of Physalis alkekengi extracts on quorum sensing and virulence gene expression in uropathogenic E. coli.
  • Examined ethanolic and aqueous extracts of Physalis alkekengi.
  • Used agar well diffusion, disk diffusion, and broth microdilution to assess antibacterial activity on E. coli isolates.
  • Measured biofilm inhibition using microtiter plates and gene expression via real-time PCR.
  • Ethanolic extract completely inhibited EC3 at 10 mg/mL; no minimum bactericidal concentration for EC1 or EC2 with aqueous extract.
  • Ethanolic extract reduced biofilm formation by approximately 63% in EC2.
  • Downregulation of luxS and fimH expression was significant (p < 0.05) with the ethanolic extract.

Cite This Study

Doolaby et al. (2026) studied this question.

synapsesocial.com/papers/6a2115d7d499ed480b16ed2ahttps://doi.org/10.1111/1758-2229.70371
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