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October 2, 2025Annual Review of Cell and Developmental BiologyOpen Access

Mechanisms of Messenger RNA Packaging and Export

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Authors

RFRupert FarawayDZDaniel ZenklusenCPClemens Plaschka

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Overview

This review discusses mRNA packaging and export mechanisms in eukaryotes, indicating critical roles in gene expression.

Key Points

  • Messenger RNA packaging and export are vital for gene expression in eukaryotic cells, ensuring proper mRNA processing and transport.
  • The review outlines roles of mRNA ribonucleoproteins (mRNPs) in compacting mRNA and facilitating its export through the nuclear pore complex (NPC).
  • Insights from genetics and biochemistry inform understanding of mRNA biogenesis and highlight pathways for quality control and regulatory mechanisms.
  • Open questions remain about specific mRNP packaging mechanisms, export processes, and how they are regulated in the cellular context.

Cite This Study

Faraway et al. (2025) studied this question.

synapsesocial.com/papers/68de5da283cbc991d0a20746https://doi.org/10.1146/annurev-cellbio-101123-045256
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