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October 2, 2025ACS Infectious Diseases

Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival

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Authors

XJXiao JinHYHaihao YanXCXiaolin Chen

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Overview

Experimental analysis reveals Rv2647 inhibits pyroptosis in macrophages, suggesting a mechanism for M. tuberculosis evasion.

Key Points

  • Rv2647 promotes NLRP3 ubiquitination, reducing macrophage pyroptosis and enhancing M. tuberculosis survival.
  • Inhibition of NLRP3/caspase-1/GSDMD signaling reduces IL-1β secretion, critical for inflammatory response.
  • This study identifies Rv2647 as a key virulence factor that aids M. tuberculosis in escaping immune defenses.
  • Competitively inhibiting ISGylation of NLRP3 through ISG15 binding demonstrates a novel mechanism of immune evasion.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68de5da283cbc991d0a2097ehttps://doi.org/10.1021/acsinfecdis.5c00192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depletion of Mycobacterium tuberculosis transmembrane protein Rv3737 reduces pathogen survival and induces M1 macrophage polarization against tuberculosis2025 · 3 citations
  2. 2The Ubiquitination of Mycobacterium tuberculosis Rv3717 Promotes Proteasomal Degradation of Interleukin Enhancer-Binding Factor2025
  3. 3Rv1983 promotes mycobacterial dissemination by triggering ferroptosis through GPX4 ubiquitination2026
  4. 4<i>Mycobacterium tuberculosis</i> does not inhibit NLRP1 and pyrin inflammasomes in human macrophages2026
  5. 5Characterization of a novel Mycobacterium tuberculosis serine protease Rv1815 in regulating bacterial metabolism and macrophage intracellular survival2026