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September 5, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Depletion of Mycobacterium tuberculosis transmembrane protein Rv3737 reduces pathogen survival and induces M1 macrophage polarization against tuberculosis

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Authors

ZPZhangli PengCXChao XuTYTao You

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Overview

Study shows Rv3737 depletion enhances M1 macrophage polarization and reduces Mycobacterium tuberculosis survival.

Key Points

  • Depletion of Rv3737 enhances M1 macrophage polarization, leading to decreased pathogen survival.
  • Key markers such as TNF-α and iNOS increased significantly, indicating a stronger antimicrobial response.
  • Analysis involved RNA sequencing and various pathway assessments to explore macrophage responses.
  • Targeting Rv3737 provides a potential new direction for developing tuberculosis treatments.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68bb4dfb6d6d5674bcd024c0https://doi.org/10.3389/fcimb.2025.1592296
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