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October 2, 2025Open Access

The Effects of DMSO Cryopreservation on the Biomechanics and Histology of Human Cerebrovascular Tissue

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Authors

MMMaximos McCuneCleveland ClinicMDMark A. DavisonCleveland ClinicNTNishanth ThiyagarajahCleveland Clinic

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Implication

Experimental analysis reveals DMSO cryopreservation alters cerebrovascular tissue biomechanics and histology.

Key Points

  • DMSO cryopreservation did not consistently protect cerebrovascular specimens, impacting tissue integrity.
  • Cryopreserved tissues showed swelling in vessel tunics and increased elastin breaks compared to controls.
  • This examination used tissue specimens from cadaver donors to assess the impacts of preservation methods.
  • Findings suggest preservation methods may fail to maintain vascular properties, affecting future testing.

Cite This Study

McCune et al. (2025) studied this question.

synapsesocial.com/papers/68de5da783cbc991d0a20b70https://doi.org/10.1101/2025.09.29.679363
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