Protocol demonstrates Michael addition followed by acid-mediated cyclization, yielding thiophenes in good yields.
Herein, we report a practical synthesis of 2,5-disubstituted thiophenes. The protocol features an initial base-promoted Michael addition of 4-methoxybenzyl mercaptan to β-nitro-β,γ-unsaturated ketones, followed by an acid-mediated cyclization of the resulting adducts. This one-pot procedure affords the desired thiophene derivatives in good overall yields.
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Bentivogli et al. (2025) studied this question.
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