October 2, 2025Open Access

Contrasting mutation patterns in haploid and diploid cells from two yeast species

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Experiment reveals higher mutation rates in diploid cells of Schizosaccharomyces pombe, suggesting genetic drift influences mutation patterns.

Higher mutation rates were observed in diploid cells of Schizosaccharomyces pombe, supporting predictions based on genetic drift.
The results indicate that mutation patterns vary significantly between haploid and diploid cells in different yeast species.
Natural selection appears limited in influencing mutation rates, particularly in rarer cell types within populations.
Both species studied showed that ploidy state impacts the spectrum of mutations, highlighting evolutionary dynamics.

Bao et al. (2025) studied this question.

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Experiment reveals higher mutation rates in diploid cells of Schizosaccharomyces pombe, suggesting genetic drift influences mutation patterns.