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October 2, 2025Modern Rheumatology Case Reports

A case of SARS-CoV-2 infection during the course of SLE difficult to differentiate NPSLE from multisystem inflammatory syndrome in adults (MIS-A)

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Authors

TST. SonodaKyushu UniversitySIS. IwataWakayama Medical UniversityKTKatsunori TanakaWakayama Medical University

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Overview

Case report describes MIS-A in a systemic lupus erythematosus patient, highlighting diagnostic challenges and implications.

Key Points

  • Patient developed multisystem inflammatory syndrome after sars-cov-2 infection, complicating sle diagnosis.
  • MIS-A criteria were met, with severe crp elevation and neuropsychiatric symptoms observed after covid infection.
  • MRI findings showed brain abnormalities, indicating central nervous system involvement, complicating sle assessment.
  • Treatment included corticosteroids and immunoglobulin therapy, leading to resolution of symptoms and improved MRI results.

Cite This Study

Sonoda et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a20f16https://doi.org/10.1093/mrcr/rxaf061
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adult Multissystem Inflamatory Síndrome (MIS-A): case report2024
  2. 2Post-Coronavirus Disease-2019-associated Multisystem Inflammatory Syndrome in Adults: A Case from India.2025
  3. 3Rare disease mimicking Multisystem İnflammatory Syndrome In Children2025
  4. 4COVID‐19 infection triggered juvenile systemic lupus erythematosus‐like disease2022 · 7 citations
  5. 5When Viral Seropositivity Obscures Autoimmunity: Multisystem SLE with Concurrent CMV Positivity in an Immunocompetent Patient2026