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October 2, 2025Siberian Journal of OncologyOpen Access

The role of immune proteasomes in the mechanisms of lymphatic metastasis in non-small cell lung cancer

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Authors

ESE. A. SidenkoГКГ. В. КакуринаNYN. V. Yunusova

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Overview

Review examines immune proteasomes' involvement in lymphatic metastasis and implications for treatment in non-small cell lung cancer.

Key Points

  • Immune proteasomes play a key role in lymphatic metastasis in non-small cell lung cancer.
  • Increased expression of PSMB8 and PSMB9 genes is linked to non-small cell lung cancer cell cultures.
  • Regulation of angiogenesis and cell locomotion processes by proteasomes has been noted.
  • Immunoproteasomes may serve as a promising therapeutic target in cisplatin-resistant lung cancer.

Cite This Study

Sidenko et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a20fb7https://doi.org/10.21294/1814-4861-2025-24-4-147-154
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 7013: Proteogenomic analysis identifies the association of cytoskeleton-related molecules with immunosuppressive state of small cell lung cancer2026
  2. 2Immunoproteasome components LMP2, PSME1, and PSME2 as novel tissue biomarkers predicting response and survival in neoadjuvant chemoimmunotherapy for resectable NSCLC2025
  3. 3Dissecting origin factors of lymph node metastasis in non-small cell lung cancer via multimodal omics2026 · 1 citations
  4. 4Abstract 5434: Immune cell infiltration analysis of lung cancer based on proteomics.2026
  5. 5The role of long non‐coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications2025 · 10 citations