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Comparative analysis reveals urinary extracellular miRNAs may act as diagnostic markers for CRPC, highlighting their potential in treatment.
Background. Castration-resistant prostate cancer (CRPC) is a highly aggressive and challenging-to-treat cancer. the search for markers to predict early CRPC for timely treatment adjustments and further study of these markers as potential targets for new CRPC therapies is a crucial task in modern molecular biology and medicine. extracellular miRnas show promise as diagnostic and prognostic markers for prostate cancer (PC) and particular for CRPC. Aim of the study: a comparative analysis of the expression of 14 miRnas in the urine supernatant of patients with hormone-sensitive prostate cancer (HsPC), CRPC, and donors (D). Material and Methods. the analysis was conducted using the real-time qPCR. a pairwise normalization method was used to search for diagnostic miRna expression signatures. Results. twenty-nine differentially expressed pairs of miRnas were identified. In this case, miRna-375 was included in the largest number (n=7) of diagnostically significant pairs. three miRna pairs (miRna-144/222; 205/375; 222/125) showed the highest sensitivity and specificity in diagnosing CRPC when using both HsPC patients alone and the combined group of donors and HsPC patients as the control group. Conclusion. the results obtained indicate that the assessment of the relative expression of urinary extracellular miRnas has a significant potential for diagnosing highly aggressive castration-resistant prostate cancer.
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Saitkulova et al. (2025) studied this question.
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