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October 2, 2025Siberian Journal of OncologyOpen Access

Urinary extracellular miRNAs as potential biomarkers for castration-resistant prostate cancer

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Authors

MSMilena SaitkulovaOBOlga E. BryzgunovaIOIlya Ostaltsev

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Overview

Comparative analysis reveals urinary extracellular miRNAs may act as diagnostic markers for CRPC, highlighting their potential in treatment.

Key Points

  • Urinary extracellular miRNAs show high potential for diagnosing castration-resistant prostate cancer.
  • A total of 29 differentially expressed pairs of miRNAs were identified, with miRNA-375 being most significant.
  • Three miRNA pairs demonstrated the highest sensitivity and specificity for diagnosing CRPC in comparison with controls.
  • Results suggest urinary biomarkers could enhance early detection and treatment of aggressive prostate cancer.

Cite This Study

Saitkulova et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a20fe7https://doi.org/10.21294/1814-4861-2025-24-4-82-92
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MiRNA based liquid biopsy for castration-resistant prostate cancer diagnostics2026
  2. 2Extracellular RNAs from Whole Urine to Distinguish Prostate Cancer from Benign Prostatic Hyperplasia2024 · 7 citations
  3. 3Abstract 5321: Comprehensive profiling of urine microRNAs in prostate cancer patients.2026
  4. 4Evaluating the Urinary Exosome MicroRNA Profile in Prostate Cancer2026
  5. 5Assessment of miR-21-5p, miR-451a, and miR-144-3p level in urine in differential diagnosis of localized prostate cancer2024